Antibody Fc. Linking Adaptive and Innate Immunity by Margaret Ackerman, Falk Nimmerjahn PDF

By Margaret Ackerman, Falk Nimmerjahn

ISBN-10: 0123948029

ISBN-13: 9780123948021

Antibody Fc is the 1st unmarried textual content to synthesize the literature at the mechanisms underlying the dramatic variability of antibodies to steer the immune reaction. The booklet demonstrates the significance of the Fc area, together with protecting mechanisms, effector phone varieties, genetic facts, and variability in Fc area functionality. This quantity is a serious single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers in addition to graduate scholars in immunology and vaccinology.

Antibodies symbolize the correlate of safety for various vaccines and are the main swiftly growing to be classification of gear, with functions starting from melanoma and infectious affliction to autoimmunity. Researchers have lengthy understood the variable area of antibodies, that are chargeable for antigen acceptance, and will offer safeguard via blocking off the functionality in their goal antigen. even if, fresh advancements in our figuring out of the security mediated by way of antibodies have highlighted the serious nature of the antibody consistent, or Fc area, within the organic job of antibodies. The Fc area permits antibodies to hyperlink the adaptive and innate immune platforms, offering specificity to a variety of innate effector cells. additionally, they supply a suggestions loop to control the nature of the immune reaction through interactions with B cells and antigen-presenting cells.

  • Clarifies different mechanisms of IgG task on the point of the several version structures used, together with human genetic, mouse, and in vitro
  • Covers the position of antibodies in melanoma, infectious disorder, and autoimmunity and within the environment of monoclonal antibody remedy in addition to evidently raised antibodies
  • Color illustrations increase reasons of the immune system

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Additional info for Antibody Fc. Linking Adaptive and Innate Immunity

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Immunity 2006;24(3):305–16. Anderson KE, Chessa TA, Davidson K, Henderson RB, Walker S, Tolmachova T, et al. PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcRmediated phagocytosis in primary mouse neutrophils. Blood 2010;116(23):4978–89. Muta T, Kurosaki T, Misulovin Z, Sanchez M, Nussenzweig MC, Ravetch JVA. 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling. Nature 1994;368(6466):70–3. Ono M, Bolland S, Tempst P, Ravetch JV.

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Antibody Fc. Linking Adaptive and Innate Immunity by Margaret Ackerman, Falk Nimmerjahn

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