Download PDF by Karl S. Drlica, David S. Perlin: Antibiotic Resistance: Understanding and Responding to an

By Karl S. Drlica, David S. Perlin

ISBN-10: 0131387731

ISBN-13: 9780131387737

As pathogenic micro organism evolve, antibiotic resistance is spreading, compromising our skill to manage and deal with infectious ailments. Antibiotic Resistance completely illuminates this significant factor for healthcare pros, researchers, scholars, and policymakers. prime investigators clarify what resistance is, the way it emerges, which human actions give a contribution, and the way to reinforce our defenses.

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Extra info for Antibiotic Resistance: Understanding and Responding to an Emerging Crisis

Sample text

Short nucleic acid strands made in the laboratory serve as probes that bind specifically to nucleic acids of particular pathogens. Nucleic acid tests are rapid, specific, and sensitive. Demonstrating that a specific life form is responsible for a particular infection is central to understanding infectious disease. Causality is established by a set of criteria called Koch’s postulates. Because new infections continue to emerge, Koch’s postulates remain relevant, even though they are more than 120 years old.

Aureus from the noses of healthcare workers and newly admitted hospital patients during efforts to eradicate staphylococci and MRSA from hospitals. Linezolid is a member of the oxazolidinones, the newest group of antibacterial agents. Linezolid blocks initiation of protein synthesis by binding to the small ribosome subunit, preventing it from joining with the large subunit. The drug is used mainly for treatment of infections caused by Gram-positive pathogens, because linezolid has almost no activity with Gram-negative bacteria.

For example, the bioterror agent ricin, which is extremely toxic to humans, acts by inactivating ribosomes, the workbenches where proteins are made. Bacterial ribosomes are composed of two subunits (one called small or 30S and the other called large or 50S). The two ribosome subunits, which must come together for protein synthesis to occur, are composed of large RNA molecules (rRNA) and about 50 different proteins. As an early step in the process, more than 20 enzymes (aminoacyl tRNA synthetases) individually connect more than 20 transfer RNAs to 20 different amino acids.

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Antibiotic Resistance: Understanding and Responding to an Emerging Crisis by Karl S. Drlica, David S. Perlin


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