By Frank J. Dixon and Henry G. Kunkel (Eds.)
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Extra resources for Advances in Immunology, Vol. 24
B. Fate of Other Ligands . . . . . C . Antigenic Modulation . . . . . VII . Relationship of Surface Components with Each Other and with Intramembranous Particles . . . . . . A . Relationship between Two Surface Molecules . . . B. Relationship of Surface Molecules and Intramembranous Particles . VIII. Late Effects of Anti-Ig Antibodies . . . . . . . . . A . Regeneration of Surface Ig B. Anti-Ig-Induced Inactivation of Early B Cells . . . C . Stimulatory or Inhibitory Effects of Anti-Ig Antibodies .
Med. 104, 383. 135. Lay, W. , and Nussenzweig, V. ( 1968). J . Exp. Med. 128,991. 136. Leon, M. A. (1961). In “Immunochemical Approaches to Problems in Microbiology” (M. Heidelberger, and 0. J. ), p. 304. Rutgers Univ. Press, New Brunswick, New Jersey. 137. , and Dierich, M. (1974). J. lmmunol. 112, 935. 138. , and Bitter-Suermann, D. (1974). Fed. , Fed. Am. SOC. Exp. Biol. 33, 775. 139. Lowbury, E. , and Ricketts, C. R. ( 1957). J. H y g . 55, 266. 140. Marcus, R. , Shin, H. , and Mayer, M. M.
Pathological in uiuo and in uitro tests are restored to near normal upon infusion of fresh plasma or purified C3 INA (10, 274). The findings obtained by the study of this unique patient have established the important biological role of C3b INA as an inhibitor of the feedback mechanism of the alternative pathway. They also suggest that C3b is continuously generated in uivo by an as yet unknown mechanism. A homozygous deficiency of C3 was first observed by Alper et al. in 1972 (12, 1 3 ) . In the meantime two other cases of the complete absence THE ALTERNATIVE PATHWAY OF COMPLEMENT ACTIVATION 23 of C3 have been reported (12, 1 5 ) .
Advances in Immunology, Vol. 24 by Frank J. Dixon and Henry G. Kunkel (Eds.)