By Ivan Mura (auth.), Luis F. Castillo, Marco Cristancho, Gustavo Isaza, Andrés Pinzón, Juan Manuel Corchado Rodríguez (eds.)
This quantity compiles approved contributions for the 2d variation of the Colombian Computational Biology and Bioinformatics Congress CCBCOL, after a rigorous evaluate procedure during which fifty four papers have been accredited for booklet from 119 submitted contributions. Bioinformatics and Computational Biology are components of information that experience emerged because of advances that experience taken position within the organic Sciences and its integration with info Sciences. the growth of initiatives concerning the research of genomes has led the way in which within the creation of colossal quantities of series facts which should be prepared, analyzed and kept to appreciate phenomena linked to dwelling organisms relating to their evolution, habit in several ecosystems, and the improvement of purposes that may be derived from this analysis.
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Additional resources for Advances in Computational Biology: Proceedings of the 2nd Colombian Congress on Computational Biology and Bioinformatics (CCBCOL)
G. E- cadherin and integrins) and G-protein-coupled receptors (GPCR). Furthermore, it has been noticed that the EGFR is able to interact with other receptors and perform transactivavion signaling by virtue of the fact that it does not require binding of its ligand for tyrosine kinase activity and dimerization [8,9]. Previous research have shown that in certain types of tumors such as glioblastoma, Mul tiforme have shown overexpression of both EGFR and PDGFR (platelet derived growth factor) that can contribute to the malignant phenothype of glioblastoma [10,11].
Bioinformatics 22, 195–201 (2006) 29. : Toward the estimation of the absolute quality of individual protein structure models. Bioinformatics 27, 343–350 (2011) 30. : Platelet-derived growth factor: Identification of constituent polypeptide chains Biochem. Biophys. Res. Commun. 104, 66–71 (1982) 31. : Human platelet-derived growth factor. Purification and resolution into two active protein fractions. J. Biol. Chem. 256, 8896–8899 (1981) 32. : Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes.
Leal, C. L´ opez, and L. L´ opez-Kleine in the network . Once GCNs are constructed, they can be analyzed in order to provide functional annotations for genes which’s function is unknown . Besides, GCNs have been useful in studies of translational functional genomics such as networks alignment  and comparisons based on graph variables . During the last case, networks have mainly been described by topological variables and a principal component analysis (PCA) on these variables has been applied to characterize them.
Advances in Computational Biology: Proceedings of the 2nd Colombian Congress on Computational Biology and Bioinformatics (CCBCOL) by Ivan Mura (auth.), Luis F. Castillo, Marco Cristancho, Gustavo Isaza, Andrés Pinzón, Juan Manuel Corchado Rodríguez (eds.)